A new study published in the Journal of the American Medical Association found that people who were hospitalized with COVID-19 during past flu seasons were more likely to die than those who were hospitalized with the flu, especially if they were vaccinated against the coronavirus. if you have not received it.
The study was funded by the U.S. Department of Veterans Affairs and conducted by researchers Yan Xie, Taeyoung Choi, and Ziyad Al-Aly working at the Center for Clinical Epidemiology, VA St. Louis Health Care System. The findings, released Thursday, show that between Oct. 1, 2022 and Jan. 31, 2023, he was hospitalized with 11,399 mostly older male veterans who were hospitalized with COVID-19 or the flu. Based on data from
Xie, Choi, and Al-Aly found that 538 of 8,996 hospitalized patients with COVID-19 died, and 76 of 2,403 hospitalized patients with influenza died. In other words, 5.98% of patients hospitalized with COVID-19 died within his 30 days, compared to 3.16% of those with influenza. During the study period, hospitalizations for COVID-19 were two to three times higher than those for influenza.
“In this study, hospitalization for COVID-19 and seasonal influenza was associated with an increased risk of mortality in the fall (and) winter (and) winter 2023 (veterans) population. Understood,” the authors wrote. Fortunately, we also found that the mortality rate for people hospitalized with COVID-19 has declined compared to early in the pandemic, when he was 17-21% in 2020.
“The decline in mortality among people hospitalized with COVID-19 may be due to changes in SARS-CoV-2 variants, increased levels of immunity from vaccination and previous infections, and improved clinical care,” they said. is writing
“The increased risk of death was higher in unvaccinated people compared to vaccinated or boosted people. It is the result of emphasizing sexuality.”
Method
Xie, Choi, and Al-Aly used the U.S. Department of Veterans Affairs electronic health database to screen all persons with at least one hospitalization record between 2 days before and 10 days after a positive SARS-CoV test result. registered in the database. 2 or influenza, and hospitalization diagnosis of COVID-19 or seasonal influenza. They excluded those diagnosed with both.
We adjusted for variables such as age when analyzing the data. Smoking status; History of COVID-19 infection; Long-term care use; Blood pressure; Steroid use; and immune dysfunction; liver and peripheral artery disease; outpatient visits and hospitalizations, number of medications. Medicare use; admission dates, bed capacity and occupancy.
They assessed mortality risk in people hospitalized with COVID-19 and influenza through an inverse probability-weighted Cox survival model. They used a statistical model called logistic regression to generate propensity scores, which they applied to inverse probability weighting to balance the two groups. Estimated. Specifically, the difference in mortality between her COVID-19 and influenza groups at 30 days. They also examined the risk of prespecified subgroups based on age, vaccination status, SARS-CoV-2 infection status, and use of prehospital outpatient COVID-19 antiviral therapy.
